TC: Taxotere and Cyclophosphamide
It is a combination of two chemotherapy medicines:
Cyclophosphamide is a type of chemotherapy medicine called an alkylating agent.
Docetaxel works by damaging the structure or the “skeleton” that supports cancer cells. This stops the cancer cells from growing and dividing.
Cyclophosphamide attaches to and damages the DNA in cancer cells when they are in their resting phase (not dividing). After their DNA is damaged, the cells can’t keep dividing, and their growth slows or stops.
TC is one option used to treat people with localized breast cancer that requires chemotherapy. Unlike some other regimens given for localized breast cancer, TC does not contain an anthracycline. If you have heart health issues, your providers may offer this regimen since anthracyclines like doxorubicin (Adriamycin) cannot be given to people with heart problems.
You and your doctor will discuss the best chemotherapy treatment for your situation.
Common side effects of TC include:
- Allergic reaction
- Increased risk of infection
- Nausea and vomiting
- Hair loss
- Loss of appetite
- Mouth sores
- Menopausal symptoms
- Nail changes
- Bladder irritation
- Eye irritation
- Increased risk of sunburn
- Bone and joint pain
- Low red and white blood cell counts
- Neuropathy (numbness or tingling in the hands and feet)
- Diarrhea or constipation
- Hand and Foot Syndrome
Less common side effects include:
Before starting TC, tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counter medicines, to make sure they won’t interfere with your chemotherapy treatment.
You should avoid becoming pregnant while you are receiving TC. Tell your doctor right away if you become pregnant while you are undergoing treatment.