Ixabepilone is FDA approved to be used alone or with capecitabine (Xeloda) to treat locally advanced or metastatic breast cancer. It is used to treat cancers that have grown despite treatment with other chemotherapy, including anthracyclines and taxanes.
Ixabepilone may be used in all types of breast cancer, including triple-negative metastatic breast cancer.
Ixabepilone is given by vein through an IV, either alone or with the chemotherapy medicine capecitabine, once every 3 weeks. Because ixabepilone can cause an allergic reaction, you will be given steroid medicines right before treatment to prevent a reaction.
You and your doctor will discuss how many cycles you will have.
Common side effects include:
- Loss of appetite
- Problems with toenails and fingernails
- Hair loss
- Hand-foot syndrome
- Mouth sores
- Neuropathy, numbness or tingling in the hands and feet
- Neutropenia (low white blood cell count, which carries a risk of infection) and other low blood counts
- Allergic reactions such as itching, rash or breathing troubles
Other side effects include:
Before starting ixabepilone, tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the- counter medicines. Also tell your providers about all your medical conditions including liver problems, heart problems, diabetes and neuropathy (numbness in your hands and feet).
Do not drink grapefruit juice while you are on ixabepilone. It can cause you to have too much of the medicine in your blood and lead to side effects.
You should avoid becoming pregnant while you are receiving ixabepilone. Tell your doctor right away if you become pregnant or may be pregnant while you are undergoing treatment.