Signs Breast Cancer May Be BRCA-Related

August 31, 2015
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Certain patterns in your family’s health history may suggest that you or your relatives carry a geneinfo-icon mutationinfo-icon linked to breast cancer.

Research shows your family may carry a gene mutation linked to breast cancer if:

  • You were young at diagnosisinfo-icon. Typically, breast cancer occurs in older women. The younger you are at diagnosis, the more likely the breast cancer is related to a gene mutation. National guidelines recommend BRCA testing if you were diagnosed at or before age 45
  • You have a certain type of breast cancer. Triple-negative breast cancer, especially when diagnosed at a younger age, may be associated with a gene mutation
  • You had two separate breast cancer diagnoses. If you had breast cancer in the past and were later diagnosed with a second, new breast cancer, a gene mutation might play a role
  • You have breast cancer and a strong family history of breast or ovarian cancerinfo-icon. Women with BRCA mutations are at risk for both breast and ovarian cancer. If there is a strong history of either in your family, inheritedinfo-icon gene mutation might be the cause. You can inherit gene mutations from both your mother and your father

A strong family history includes:

  • Several relatives on your mother’s or father’s side with breast or ovarian cancer
  • One or more first-degree relatives with breast or ovarian cancer, especially if diagnosed at young ages. First-degree relatives are your parents, brothers, sisters or children.
  • Family members with both breast and ovarian cancer
  • Any cases of breast cancer in men in your family
  • A close relative with ovarian cancer; between 10 and 15 percent of ovarianinfo-icon cancers are associated with a BRCA mutation
  • Your family is of a certain ethnic origin. People of Ashkenazi (Central-Eastern European) Jewish descent are almost 10 times more likely to carry a breast cancer-related gene mutation than people of other ethnic backgrounds

What If You Don't Have Breast Cancer?

If you have not been diagnosed with breast cancer, you may still be concerned about your risk of getting breast or ovarian cancerinfo-icon. You may already know a geneinfo-icon mutationinfo-icon exists in your family and wonder if you carry it yourself.

National testing guidelines recommend that the first person who gets tested in a family already be diagnosed with breast cancer. If that first person tests positive, meaning that they have a geneticinfo-icon mutation, other family members may then choose to have testing themselves. If you and your healthcare providerinfo-icon believe there are other reasons to test, you may also wish to do so.

Testing Positive for a Gene Mutation

If you test positive for a geneinfo-icon mutationinfo-icon related to breast cancer, your genetic counselor will likely recommend that you have screeninginfo-icon more often than the average woman your age who is not at high risk.

Current American Cancer Society guidelines suggest women of average risk start yearly mammograms at age 40 and have a clinical breast examinfo-icon every year. Women ages 20 to 39 should also have a clinical breast exam at least every 3 years.

For women with a BRCA mutation the screening guidelines include:

Depending on your family history, you may choose to have surgeryinfo-icon or take medicineinfo-icon to help lower your risk of developing cancer. When you do not have breast cancer, choosing to remove the breasts or ovaries is considered prophylacticinfo-icon, or preventiveinfo-icon. Treatment with a medicine like tamoxifen or raloxifeneinfo-icon is also an option, and is known as chemopreventioninfo-icon.

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