Larry Norton, MD
Senior Vice President, Norna S. Sarofim Chair in Clinical Oncology; Medical Director, Evelyn H. Lauder Breast Center, Memorial Sloan-Kettering Cancer Center
Highlights
- LBBC Medical Advisory Board member
- Senior Vice President, MSKCC
- Medical Director of the Evenlyn H. Lauder Breast Center at MSKCC
- Professor of medicine at the Weill Medical College of Cornell Universit
Larry Norton, MD, is vice president in the office of the president at Memorial Sloan Kettering Cancer Center in New York and medical director of MSK’s Evelyn H. Lauder Breast Center. He is also a professor of medicine at Weill Medical College of Cornell University in Ithaca, New York. He has dedicated his career to the eradication of cancer through medical care, laboratory and clinical research, advocacy, and government service.
Dr. Norton is the principal investigator of a National Cancer Institute program project grant in models of human breast cancer. He is the founding incumbent of the Norna S. Sarofim Chair of Clinical Oncology at MSK and a founder of the Breast Cancer Research Foundation, where he serves as scientific director.
He has held leadership roles in numerous organizations, including the American Society of Clinical Oncology, the National Cancer Advisory Board, the National Cancer Institute, the National Institutes of Health, the Institute of Medicine of the National Academy of Sciences, and the breast committee of the Cancer and Leukemia Group B. He is an editorial board member and reviewer for multiple medical journals and has authored more than 350 articles and numerous book chapters.
Dr. Norton has served as a visiting professor at institutions across the United States, Canada, South America, Europe, and Asia. His research focuses on developing approaches to diagnosing, preventing, and treating cancer, with an emphasis on applying mathematical models to optimize drug dosing and scheduling. He has contributed to the development of several groundbreaking therapies, including paclitaxel (Taxol) and trastuzumab (Herceptin). He co-invented the Norton-Simon Model of cancer growth, which has significantly influenced cancer treatment, and introduced the self-seeding concept of cancer metastasis and growth.
Dr. Norton has received numerous honors from institutions such as MD Anderson Cancer Center, the Society for MSK, Susan G. Komen, and the Breast Cancer Research Foundation. He was awarded the American Society of Clinical Oncology’s highest honor, the David A. Karnofsky Award, and served as a McGuire Lecturer at the San Antonio Breast Cancer Symposium.
Experience & accolades
Expertise
- Breast oncology
- Hereditary conditions
Education
- Columbia University
- Doctor of Medicine
- University of Rochester
- Bachelors of psychology
Experience
- Soroka Medical Center (2020-Present)
- Senior research advisor
- Memorial Sloan-Kettering Cancer Center (1988-Present)
- Senior vice president
- Associate director for clinical and translational science
- Deputy physician-in-chief for breast programs
- Medical director
- Head, breast disease management team
- Member, Memorial Hospital
- Associate member, Memorial Hospital
- Memorial Hospital for Cancer and Allied Diseases (1988-2003)
- Head, division of solid tumor oncology
- Chief, breast oncology service
- Chief, division of solid tumor oncology and breast & gynecologic oncology
- Attending physician, department of medicine
- Associate attending physician, department of medicine
- Mount Sainai Hospital (1977-1988)
- Associate attending
- Clinical assistant
- Adjunct associate professor, department of medicine
- Adjunct associate professor, neoplastic diseases
- Associate professor, neoplastic diseases
- Assistant professor, neoplastic diseases
- National Cancer Institute (1976-1977)
- Investigator
Awards & distinctions
- Alliance for Clinical Trials in Oncology 2022 Charles Moertel Lectureship Award, 2022
- Italian-American Foundation for Cancer Research, 2021
- Election to the American Academy of Arts and Sciences Honor Award, 2021
- AACR fellows Academy Award, 2019
- Cold Spring Harbor Double Helix Medal, 2018
- David Dubinsky Humanitarian Award, 2018
Professional memberships & board positions
- American Society of Clinical Oncology
- American Association of Cancer Research
- Cell Kinetics Society
- New York Cancer Society
- Society for Immunotherapy of Cancer
Publications
- Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α. Br J Cancer, 2024
- HOG: Local Directionality Extraction via Optimal Transport. IEEE Trans Med Imaging, 2024
- Predictors of Response to CDK4/6i Retrial After Prior CDK4/6i Failure in ER+ Metastatic Breast Cancer. Res Sq [Preprint], 2024
- Dose dense doxorubicin plus cyclophosphamide in a modified KEYNOTE52 regimen for triple negative breast cancer. Nature, 2024
- New Frontiers in the Role of Locoregional Therapies in Breast Cancer: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel. J Vasc Interv Radiol, 2023