Clinical trials
- Medical Review: LBBC Staff, Pallav K. Mehta, MD
Clinical trials are research studies carried out in people. They evaluate new therapies and compare the new treatments to current ones. Many clinical trials provide treatment—sometimes at reduced cost.
Thanks to clinical trials, breast cancer treatment no longer uses a one-size-fits-all approach. In many cases, we can now use more specific therapies based on the type of cancer. All these therapies were proven effective in clinical trials.
Ready to join a trial?
Search for one near you, or learn more about clinical trials below
The goal of clinical trials
Breast cancer clinical trials look at many aspects of treatment, including:
- New treatments in development
- New combinations of existing medicines or therapies
- The order in which medicines are given, called treatment sequence
- Different amounts of medicine given, called its dosing schedule
- The way that a treatment dose is given, such as by mouth or injected into a vein
- New ways to manage treatment side effects
- A treatment’s effectiveness at reducing the risk of recurrence or progression
- Surgical techniques and approaches
- Radiation therapy methods and schedules
- Effectiveness of complementary and integrative therapies
Clinical trials also study other aspects of breast cancer, such as:
- Screening methods and frequency
- New biomarker testing approaches
- Identifying inherited genetic links to cancer
- Nutrition and exercise
- Improving quality of life
Getting breast cancer treatment through a clinical trial may give you access to a new medicine or approach, or to the best standard therapy in use today.
In large clinical trials involving standard treatments, participants receive either:
- The standard treatment alone
- The standard treatment plus the treatment under study
- The standard treatment plus a placebo (inactive treatment)
In smaller clinical trials, participants may just receive the treatment under study. The goal is to see whether the study treatment is effective or, in some cases, just to see whether it’s safe.
As you talk with your doctors about any clinical trials they may recommend, ask about the goals of the trial and why they think you’re a good candidate for it.
Taking part in clinical trials
Breast cancer clinical trials are for women or men with early-stage or metastatic disease of all subtypes. Trials are essential to improving existing treatments and finding new treatments.
You can ask your healthcare team about clinical trials any time you are planning treatment or considering a new treatment. Many trials are only open to people who haven’t had any treatment yet. Other studies are designed for people who had cancer treatment in the past or are living with metastatic breast cancer and have had many different treatments.
Taking part in a clinical trial is often like receiving treatment outside a trial. If you enroll in a trial:
- You will be taken through the informed consent process, which includes:
- Reading a consent form that explains the purpose of the research, how long it will take, what is involved, risks and benefits, how your information will be kept private, and your rights as a participant
- Having as much time as you need to review the form and to ask any questions about anything that is not clear
- Signing the form
- You will have a medical team with a doctor-researcher responsible for your care
- You’ll also be assigned a clinical trial coordinator to answer your questions and address your concerns.
- In some cases, your trial medicine can be given at your own treatment center, so you can continue to see the care team you already have.
Types of clinical trials
Clinical trials are designed in different ways to ensure that there is reduced risk of bias and that the study results will be valid:
- Randomized studies are trials in which people are chosen at random (by chance) to receive the standard treatment or a new treatment.
- Blind studies are trials in which either the doctors, the participants, or both do not know what treatment the participant is receiving.
- Double-blind studies are trials in which neither the doctors nor the participants know what treatment the participant is receiving.
What are the benefits and risks of clinical trials?
If you’re interested in joining a clinical trial, consider your options and what’s important to you. A clinical trial may help you get a new treatment, but it could impact your life in other ways, too.
Participating in a clinical trial is voluntary, but not everyone can join every trial. If you are eligible for a specific study, talk about the pros and cons with the study team, your care team, and people close to you. Consider these benefits and risks:
Benefits of clinical trials
- You may receive new medicines, combinations of medicines or try treatment methods that are not available outside of the clinical trial. These may be more effective or have fewer side effects than the current standard treatment.
- If a new treatment works, you may benefit from it before it is available to the public.
- You will always receive at least the current standard treatment recommended for you.
- Doctors and nurses on the study team will closely monitor your treatment, often more closely than in standard breast cancer care. An independent safety committee charged with keeping the trial participants safe from harm also watches over your care.
- The costs of some trials and trial medicines are covered by insurance or other programs or are free to participants.
You may feel good knowing your participation could help others affected by breast cancer in the future.
Risks of clinical trials
- In a randomized trial, you won’t be able to choose your treatment.
- Remember that although you might not get the new treatment, you will still get the standard treatment appropriate for your care.
- The new treatment being tested might not be more effective than the standard therapy. Still, here are some things to keep in mind:
- In a randomized trial, you will always get at least the standard of care.
- If you are in a trial in which you could receive the standard treatment plus the treatment under study, even if the new treatment isn’t effective, you may still benefit from the standard treatment you are taking.
- You may have side effects that are worse than those caused by the standard treatment or side effects previously unknown to researchers.
- You may have to pay costs for medicines, tests, and doctor visits related to the trial that your health insurance might not cover.
- Ask the study team and your insurer what will be covered.
- Check your informed consent document to see what costs you could have.
- You may need to take extra time away from work or your personal life, or have more travel or childcare costs, because of the study. However, in some cases, the study may cover some expenses. If you meet certain criteria, the federal Family and Medical Leave Act of 1993 protects you and your caregiver from losing your jobs because of time missed for medical reasons.
Keep in mind that you may leave a clinical trial at any point. Be sure to talk with the clinical trial team before deciding to stop your participation. They can help you navigate any potential challenges.
What are the phases of clinical trials?
Before clinical trials can take place in people, new treatments must be researched in animals in a lab. This ensures new therapies meet safety requirements set by the federal Food and Drug Administration, or FDA. When safety research is completed and a therapy is approved, testing in people may begin.
New treatments go through four phases, or steps, of clinical trials. Each phase is considered a single clinical trial.
The FDA reviews the findings from each completed phase. If the results meet certain criteria and the FDA approves, the next phase can begin.
The first three phases of clinical trials are the most important in researching new treatments. They are:
Phase I
- Purpose: measures safety and dose, effective dose, or the safety of a combination of two medicines that have been used separately but never together. Phase I doesn’t test how well a medicine works to treat cancer
- Trial structure: not randomized, meaning everyone in the trial receives the medicine under study
- People recruited: fewer than 50 who are healthy or have cancer. If they have cancer, it is likely other treatments no longer work to treat it.
- Length of phase: up to one year
- How many treatments move on to phase II: 70%
Phase II
- Purpose: measures how well the treatment works and watches for side effects
- Trial structure: often not randomized but sometimes randomized, meaning whether you get the new therapy is decided by chance
- People recruited: may involve fewer than 50 to up to several hundred people who have cancer; the size depends on the trial structure
- Length of phase: up to two years
- How many treatments move on to phase III: 33%
Phase III
- Purpose: compares new, safe treatment to the current standard treatment and measures side effects
- Trial structure: usually randomized, meaning whether you get the new therapy is decided by chance
- People recruited: several hundred to several thousand who are healthy or have cancer
- Length of phase: several years or more
FDA approval
After phase III is complete, the new treatment may receive FDA approval based on its findings. If it's approved, the medicine can be made and sold. It can take another 18 months to get FDA approval after phase III ends. In total, a new treatment can take between eight and 10 years to move from phase I to FDA approval.
Phase IV
For some trials, there also is a phase IV, which occurs after FDA approval. If there is a phase IV, the purpose is:
- To monitor long-term side effects of new medicines
- To collect information on the benefits of medicines in a variety of people who may not have taken part in the clinical trial, such as older people or pregnant women
How can I find clinical trials?
There are several good ways to find breast cancer clinical trials you may be eligible for:
- Ask your doctor about clinical trials when you talk about treatment options. If you need to change treatment for any reason, consider joining a trial.
- Request a second opinion from a doctor who conducts clinical trials.
- Search online:
- Before starting, review your pathology report and test results, so you know if you match the medical criteria for specific studies.
- Early-stage trial search can make it easier to find clinical trials for early stage breast cancer therapies and other approaches.
- Metastatic trial search can make it easier to find clinical trials for metastatic breast cancer therapies and quality-of-life approaches.
- These websites also help you search for clinical trials:
When you find trials that seem right for you, bring the details, including study number and sponsor, to your doctor and talk about your options.
Where do clinical trials take place?
Clinical trials vary greatly in size and scope. A clinical trial may be held at just one location or might be available in hundreds of places throughout the country or around the world.
Breast cancer clinical trials take place in:
- Cancer centers
- University hospitals or academic medical centers
- Large and regional hospitals
- Veterans Administration hospitals
- The National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland
- Community hospitals
- Local doctors’ offices
Not every trial is available at every site. Researchers may run clinical trials in only one, or very few, places. Cancer researchers and healthcare providers have cooperative groups that offer certain studies in multiple locations in the U.S., North America or other regions, or internationally.
Where can I participate in a clinical trial?
You may be able to participate in a clinical trial at the hospital or treatment center where you currently get care. Or your doctor may belong to a cooperative oncology research group that conducts studies. If you can’t get the study treatment at your care center but are interested, you may want to seek a second opinion from a doctor who participates in clinical trials.
If you find a clinical trial at another location and enroll, the clinical trial doctor will communicate about your treatment with your current provider, if you wish. Sometimes it’s possible to go to the clinical trial site just for enrollment and testing and then receive treatment closer to home.
More doctors are holding clinical trials in local settings than in years past. You may find these at your local hospital or doctor’s office. This helps make clinical trials available to more people.
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- preauthorization
- precancerous
- preclinical study
- predictive factor
- pregabalin
- premalignant
- premature menopause
- premenopausal
- premium
- prescription
- prevention
- preventive
- preventive mastectomy
- primary care
- primary care doctor
- primary endpoint
- primary therapy
- primary treatment
- primary tumor
- Principal investigator
- prochlorperazine
- progesterone
- progesterone receptor
- progesterone receptor-negative
- progesterone receptor-positive
- progesterone receptor test
- progestin
- prognosis
- prognostic factor
- progression
- progression-free survival
- progressive disease
- Prolia
- proliferative index
- promegapoietin
- prophylactic
- prophylactic mastectomy
- prophylactic oophorectomy
- prophylactic surgery
- prophylaxis
- prospective
- prospective cohort study
- prosthesis
- protective factor
- protein
- protein-bound paclitaxel
- protein expression
- protein expression profile
- protocol
- proton
- proton magnetic resonance spectroscopic imaging
- pruritus
- psychiatrist
- psychological
- psychologist
- psychosocial
- psychotherapy
- PTSD
- pump
- punch biopsy
- qi
- qigong
- quadrantectomy
- quality assurance
- quality of life
- radiation
- radiation brachytherapy
- radiation dermatitis
- radiation fibrosis
- radiation necrosis
- radiation nurse
- radiation oncologist
- radiation physicist
- radiation surgery
- radiation therapist
- radiation therapy
- radical lymph node dissection
- radical mastectomy
- radioactive
- radioactive drug
- radioactive seed
- radioisotope
- radiologic exam
- radiologist
- radiology
- radionuclide
- radionuclide scanning
- radiopharmaceutical
- radiosensitization
- radiosensitizer
- radiosurgery
- radiotherapy
- raloxifene
- raloxifene hydrochloride
- randomization
- randomized clinical trial
- receptor
- RECIST
- reconstructive surgeon
- reconstructive surgery
- recreational therapy
- recurrence
- recurrent cancer
- referral
- reflexology
- refractory
- refractory cancer
- regimen
- regional
- regional anesthesia
- regional cancer
- regional chemotherapy
- regional lymph node
- regional lymph node dissection
- registered dietician
- regression
- rehabilitation
- rehabilitation specialist
- relapse
- relative survival rate
- relaxation technique
- remission
- remission induction therapy
- remote brachytherapy
- research nurse
- research study
- resectable
- resected
- resection
- residual disease
- resistant cancer
- resorption
- respite care
- response rate
- retrospective cohort study
- retrospective study
- risk factor
- Rubex
- salpingo-oophorectomy
- salvage therapy
- samarium 153
- sargramostim
- scalpel
- scan
- scanner
- scintigraphy
- scintimammography
- sclerosing adenosis
- screening
- screening mammogram
- second-line therapy
- second-look surgery
- second primary cancer
- secondary cancer
- secrete
- sedative
- segmental mastectomy
- selection bias
- selective estrogen receptor modulator
- selective serotonin reuptake inhibitor
- sentinel lymph node
- sentinel lymph node biopsy
- sentinel lymph node mapping
- sepsis
- sequential AC/Taxol-Trastuzumab regimen
- sequential treatment
- SERM
- sertraline
- Serzone
- sestamibi breast imaging
- sexuality
- sibling
- side effect
- silicone
- simple mastectomy
- simulation
- Single-agent therapy
- sleep disorder
- social service
- social support
- social worker
- sodium thiosulfate
- soft tissue
- solid tumor
- somatic
- somatic mutation
- sorafenib
- specialist
- specificity
- spiculated mass
- spinal anesthesia
- spinal block
- spiral CT scan
- spirituality
- sporadic cancer
- SSRI
- stable disease
- stage
- stage 0 breast carcinoma in situ
- stage 0 disease
- stage I breast cancer
- stage IA breast cancer
- stage IB breast cancer
- stage II breast cancer
- stage II breast cancer
- stage IIA breast cancer
- stage IIB breast cancer
- stage III breast cancer
- stage III lymphedema
- stage IIIA breast cancer
- stage IIIB breast cancer
- stage IIIC breast cancer
- stage IV breast cancer
- staging
- stamina
- standard of care
- standard therapy
- statistically significant
- stent
- stereotactic biopsy
- stereotactic radiosurgery
- sterile
- sternum
- steroid
- stress
- strontium
- study agent
- subcutaneous
- subcutaneous port
- subjective improvement
- subset analysis
- supplemental nutrition
- supplementation
- support group
- supportive care
- supraclavicular lymph node
- surgeon
- surgery
- surgical biopsy
- surgical menopause
- surgical oncologist
- survival rate
- symptom
- symptom management
- symptomatic
- synergistic
- synthetic
- syringe
- systemic
- systemic chemotherapy
- systemic disease
- systemic therapy
- TAC regimen
- tai chi
- tailored intervention
- talk therapy
- tamoxifen
- targeted therapy
- taxane
- Taxol
- Taxotere
- Tc 99m sulfur colloid
- technician
- terminal disease
- therapeutic
- therapeutic touch
- therapy
- thermography
- thiethylperazine
- thiotepa
- third-line therapy
- thrush
- time to progression
- tinnitus
- tissue
- tissue flap reconstruction
- TNM staging system
- tomography
- tomotherapy
- topical
- topical chemotherapy
- topoisomerase inhibitor
- total estrogen blockade
- total mastectomy
- total nodal irradiation
- total parenteral nutrition
- toxic
- toxicity
- tracer
- traditional acupuncture
- tranquilizer
- transdermal
- transfusion
- transitional care
- translational research
- trastuzumab
- trauma
- treatment field
- trigger
- trigger point acupuncture
- triple-negative breast cancer
- tumescent mastectomy
- tumor
- tumor antigen vaccine
- tumor board review
- tumor burden
- tumor debulking
- tumor load
- tumor marker
- tumor volume
- Tykerb
- ulcer
- ulceration
- ultrasound-guided biopsy
- ultrasound/ultrasonography
- ultraviolet radiation therapy
- uncontrolled study
- undifferentiated
- unilateral
- unilateral salpingo-oophorectomy
- unresectable
- unresected
- upstaging
- urticaria
- VACB
- vaccine therapy
- vacuum-assisted biopsy or vacuum-assisted core biopsy
- Valium
- vancomycin
- vandetanib
- vascular endothelial growth factor-antisense oligonucleotide
- vascular endothelial growth factor receptor tyrosine kinase inhibitor
- vein
- Velban
- venipuncture
- venous sampling
- Versed
- vertebroplasty
- vinorelbine
- vital
- vomit
- watchful waiting
- wedge resection
- Wellcovorin
- Western medicine
- WGA study
- white blood cell
- whole cell vaccine
- whole genome association study
- wide local excision
- wire localization
- wound
- X-ray therapy
- Xanax
- Xeloda
- xerostomia
- Xgeva
- yoga
- ziconotide
- Zinecard
- Zofran
- zoledronic acid
- Zoloft
- Zometa
Living Beyond Breast Cancer is a national nonprofit organization that seeks to create a world that understands there is more than one way to have breast cancer. To fulfill its mission of providing trusted information and a community of support to those impacted by the disease, Living Beyond Breast Cancer offers on-demand emotional, practical, and evidence-based content. For over 30 years, the organization has remained committed to creating a culture of acceptance — where sharing the diversity of the lived experience of breast cancer fosters self-advocacy and hope. For more information, learn more about our programs and services.