DIEP flap
- Medical Review: Jonathan Bank, MD, FACS, Elisabeth Potter, MD, Sameer A. Patel, MD, FACS
Deep inferior epigastric artery perforator (DIEP) flap is a type of breast reconstruction surgery that uses a woman’s own abdominal fat, skin, and blood vessels to rebuild the breast or breasts after mastectomy. The tissue used to create a new breast is called a flap.
DIEP flap is one of several breast reconstruction options. Another option is implant reconstruction, which involves placing a breast implant above or under the chest muscle and skin after mastectomy. Many women who undergo DIEP flap experience more satisfaction with the way their breasts look than with other reconstruction options. Still, compared to implant-based reconstruction, tissue reconstruction generally requires a longer surgery, a longer hospital stay, and a longer time to get back to your normal activities.
On this page, we’ll explain what’s involved in a DIEP flap surgery and what to know about eligibility, side effects, complications, and insurance coverage.
What is DIEP flap surgery?
DIEP flap surgery uses a person’s own abdominal tissue to create a new breast or breasts. Unlike some other flap procedures, DIEP flap does not remove any muscles from the abdomen — just skin, fat, blood vessels, and nerves.
Some older flap reconstruction procedures, called pedicled flaps, leave the donor tissue attached to its blood supply and tunnel the tissue and blood vessels under the skin to the chest. In contrast, other flap reconstructions, including DIEP flap, completely remove the tissue from its original location and move it to the chest (a “free flap”).
Perforator flaps, including DIEP flap, use advanced techniques and have fewer side effects than other techniques because they do not remove muscle.
DIEP flap reconstruction is performed by specially trained plastic surgeons called microsurgeons. Microsurgeons use special instruments and microscopes to work with blood vessels during this surgery.
DIEP flap reconstruction can be performed immediately after mastectomy, or later (delayed reconstruction). If you’re deciding between immediate or delayed reconstruction, talk with your reconstruction surgeon about other treatments you may be having, such as chemotherapy and radiation therapy, because these can have an impact on reconstruction timing and outcome.
Who can get a DIEP flap?
With some exceptions, nearly anyone with enough abdominal fat to build one or two new breasts can get DIEP flap reconstruction after mastectomy. In the United States, it’s the most commonly performed tissue-based reconstruction.
- Of women choosing any type of breast reconstruction, including implant-based reconstruction, 17% choose DIEP flap.
- Of women who choose to have any type of tissue reconstruction, 83% choose DIEP flap.
Different breast reconstruction surgeons may have different requirements for how much abdominal fat is needed to perform DIEP flap surgery. With some approaches, women who are very thin and have little abdominal fat are not considered to be candidates for this surgery. In other cases, different planning, techniques, and incisions may be used to make DIEP flap possible for women who do not have much abdominal fat.
Previous abdominal surgery and DIEP flap eligibility
Some women are not eligible to have a DIEP flap procedure because of certain previous abdominal surgeries:
- Women who have had a prior abdominal tissue breast reconstruction, such as DIEP or TRAM flap; there may not be enough fat, skin, or blood vessels left in the abdominal tissue to perform a second procedure, so a different type of flap procedure would be recommended
- Women who have had a standard tummy tuck, because this procedure removes fat previously connected to blood vessels and can also damage blood vessels; if you gain weight later, the fat would not be in the required location for a DIEP flap
- Women who have had other abdominal operations that have affected the blood vessels required for DIEP flaps
Not all past abdominal surgeries prevent a woman from having DIEP flap reconstruction. If you’ve had a mini tummy tuck, a C-section, a hysterectomy, liposuction, or an appendectomy, you may still be a candidate for a DIEP flap.
And while prior surgeries can sometimes injure the blood vessels required to do DIEP flap surgery, in many cases, these blood vessels are not affected, and DIEP can still be performed.
Let your surgeon know if you’ve had abdominal surgery in the past. Your surgeon will evaluate your blood vessels using imaging to make sure DIEP flap is an option.
For any prior abdominal surgery, I recommend and obtain a CT angiogram to directly visualize the vessels to determine if a patient is a candidate.
Some medical conditions and lifestyle factors can affect DIEP flap eligibility
There are medical and lifestyle factors that may make DIEP flap reconstruction difficult or less likely to succeed, and may be a reason to choose another reconstruction technique. These include:
- Having uncontrolled diabetes, poor circulation, or connective tissue diseases that compromise wound healing, shrink or reduce blood vessels, or interfere with blood supply to the new breast and abdomen
- Smoking, which constricts blood vessels and can cause delayed wound healing, blood clots, thick scars, infection, and lumps caused by the death of fat cells; smoking can also lead to anesthesia-related lung complications, such as pneumonia, during this several-hour surgery
As you make decisions about DIEP flap reconstruction, visit any potential surgeons in person so you can have a physical examination. Let them know if you have any of these conditions or if you smoke. An in-person exam can help you and the surgeon confirm whether DIEP is the right procedure for you.
What happens during DIEP flap surgery
DIEP flap surgery can take 6 to 8 hours. During surgery, microsurgeons remove fat, skin, and blood vessels from the abdomen and place them in the chest to create a breast form.
The procedure requires two surgical incisions:
- One incision on the lower abdomen, from hip to hip below the navel within the bikini line
- Another incision on the chest where the breast will be built (two if you’re having both breasts reconstructed)
Microsurgeons use a microscope to clearly see each blood vessel that they cut, move, and reconnect to blood vessels in the breast area. Correctly connecting the blood vessels during DIEP flap surgery is key to the surgery’s success, because the moved tissue needs good blood supply to remain healthy.
In some cases, microsurgeons can also move a sensory nerve with the abdominal tissue. Some women report better sensation in the rebuilt breast when a nerve can be moved and reconnected to nerves in the chest that were cut during mastectomy. There is also evidence showing that nerve regeneration can happen after flap reconstruction with natural tissue.
Another option for some people is a procedure called Resensation. It uses a nerve graft made from donated human nerve tissue that connects chest nerves to tissue flap nerves. Over time, the graft guides the nerves to grow together. The goal is to restore feeling. To learn more, visit Breast reconstruction.
The surgeon will also place a drain in each incision to help remove fluid and lessen swelling over the first few weeks of recovery. Later on this page, we’ll talk about caring for drains at home after surgery. Drains are eventually removed by the surgeon.
There is a low risk of blood clots during DIEP flap surgery. If the blood vessels become blocked by a clot, the surgery will not work. Blood clots can happen if:
- There is injury to the donor tissue as it’s being removed from the abdomen; this risk is extremely low if experienced microsurgeons perform the surgery
- You have a genetic mutation that elevates clot risk
Talk with your surgeon about these and any other risks.
Recovery from DIEP flap surgery
One of the benefits of DIEP flap surgery is that its recovery time tends to be shorter than recovery from other types of tissue reconstruction because it avoids cutting muscle.
Still, it’s important to know that recovering from DIEP flap surgery takes longer than recovering from implant reconstruction. A non-medical reason that some people choose to do implant reconstruction instead is because they do not have enough time to recover slowly from a flap procedure.
Here’s what to expect after DIEP flap surgery
Immediately after surgery you’ll be taken to a hospital room, where your care team will monitor your recovery. Most people will stay in the hospital for 2-5 days after DIEP flap surgery.
Recovery at home can take anywhere from 3 to 8 weeks, though everyone’s experience is different.
Remember that two areas of your body will be recovering – your abdomen and your chest. Recovery at the hospital and at home will focus on both areas.
There will be a drain in each incision to help remove fluid and lessen swelling.
- Drains are small tubes temporarily sewn into the chest, under the arm, and into the abdomen to allow fluid to leave the incision. The drains help reduce the risk of infection from fluid build-up. This helps wounds heal faster.
- You or a caregiver will need to keep the drains clean to avoid infection; a nurse will show you how to do this before you leave the hospital, as well as how to measure how much fluid the drains are removing from your body.
- How long you have the drains depends on how long it takes your body to produce less fluid for the drains to collect. Typically, your surgeon will remove the drains around 2 weeks after surgery.
Your surgeon may ask you to wear compression garments, or binders, after surgery. Compression garments are tight-fitting, elastic clothing specially designed to put pressure on surgical areas to support tissues and lessen swelling.
- Your hospital may provide you with a compression garment or they may recommend a garment or garments you can buy.
- How long you’ll wear compression garments can vary from 2 to 8 weeks, depending on your situation and surgeon’s recommendations.
Some women choose to sleep in a recliner the first few days after surgery to keep from rolling over onto surgery wounds, or they may sleep with pillows under their knees.
As you heal, you’ll be able to add more movement to your day, working up to what you could do in the past. Your arm muscles directly impact the muscles of your chest, so you’ll need to work slowly, and your care team will advise you on movements such as lifting or reaching overhead.
Driving will be restricted while you take pain medication and while your abdominal wound heals.
You may need to wait 6-8 weeks before returning to exercise, though walking frequently is recommended to help avoid blood clots.
When to call your doctor
Call your doctor if you develop any of the following:
- Increased swelling
- Increased bruising
- Pain that doesn’t go away with medicine
- Swelling and redness along the incision that won’t go away after 1-2 days
- A fever of 100.4 degrees or more
- Green or yellow fluid coming from the incision, or fluid that smells bad
- Bleeding that does not stop with light pressure
- New loss of feeling or motion
These other symptoms can be side effects of medicine you may be prescribed. Call your doctor if you have:
- Rash
- Nausea
- Headache
- Vomiting
Questions to ask your doctor
- What should I do to prepare for surgery?
- Is there anything I need to bring to the hospital with me?
- What type of clothing should I bring for after surgery?
- Do I need to wear a bra after surgery? Will my hospital supply one to me?
- Can I drive myself home after discharge?
- How long do I need to wear compression garments?
- How do I clean my surgical drains?
- When can I take a shower?
- Am I allowed to lift heavy things/groceries/my baby? When can I start?
- Do I need physical therapy?
- When should my breasts have their “final look” (no swelling, redness, etc.)
- Who do I call if I experience complications or side effects?
- If having a family is important to me, can I still get pregnant and have a vaginal delivery after DIEP flap surgery?
DIEP flap post-surgical side effects
Post-surgical side effects are unintended issues caused by surgery. In reconstructive surgery, a side effect is any result beyond moving tissue and rebuilding the breasts, such as pain, scarring, or infection.
Side effects can be short-term, meaning they appear right after surgery and last only a few days to weeks, or long-term, meaning they appear soon after surgery but can last months to years.
The short-term side effects of DIEP flap surgery can include:
- Pain and tightness in the breast, chest, armpit, and any donor tissue sites used in breast reconstruction, such as the abdomen
- Swelling that is temporary
- Limited range of motion
- Bleeding at a surgical incision
- Infection
- Temporary loss of sensation of the breast; while some permanent numbness does happen, a lot of sensation can be recovered, depending on the amount of under-the-skin nerves preserved during mastectomy
The long-term side effects of DIEP flap surgery include:
- An increased risk of developing lymphedema , a buildup of fluid in the hand, arm, breast, chest wall, or torso on the side you had surgery, particularly if you had lymph node removal (sentinel node biopsy or axillary lymph node dissection), mastectomy, and DIEP flap surgery performed together
- Long-term lymphedema
- Scar tissue at the site of the operation, which can be stiff, a different color than the person’s overall skin tone, and irregularly shaped
All tissue flap surgeries leave scars where tissue was taken, as well as a scar on the reconstructed breast. These scars don’t go away, although they do lessen over time.
DIEP flap complications
The overall risk of post-surgery issues is relatively low with DIEP flap reconstruction, whether you have one breast reconstructed or both. Your surgical team can help you manage issues if they happen.
Unlike side effects of surgery, such as pain at the surgery site, loss of motion, and formation of scar tissue, complications of surgery are serious medical issues that develop after surgery. Like side effects, complications can be short-term or long-term, and some can be late (developing months to years later). Below is a list of short- and long-term complications that can happen after DIEP flap reconstruction, and how common each may be.
It has been over 20 years since DIEP flaps for breast reconstruction were first described, and it has become the most common method of natural tissue breast reconstruction. More and more surgeons are performing these operations worldwide, and as the collective experience has grown, the complication rates (both early and late) have plummeted. The focus has shifted from ‘doing’ the operation to providing excellent outcomes — aesthetically and functionally. In centers that focus on these procedures, safety, efficiency, and recovery are very well tolerated.
Short-term complications of DIEP flap reconstruction
Short-term complications — complications that develop soon after surgery but can be resolved in days or weeks — can include:
- Blood clot: A mass of blood that sticks to the wall of a blood vessel, potentially blocking it. Your care team may try to prevent blood clots, or treat them if found, by prescribing medicine to temporarily thin your blood.
- Hematoma: A pool of blood that collects in an organ or tissue, causing swelling and sometimes pain. Hematomas can go away on their own or may need surgery.
- Abdominal muscle weakness: Weakness that can happen if muscle fibers are split to retrieve blood vessels, which can also impact nerves that power the muscle; weakness is temporary as the muscle and nerves recover
- Abdominal bulge: A noticeable, but small, lump that forms during activities that contract the abdominal muscles
- Hernia: A condition in which part of an organ bulges through a weak portion of muscle, usually in the abdomen
Long-term complications of DIEP flap reconstruction
Long-term complications — complications that develop after surgery and can last months or years — can include:
- Scar tissue that forms lumps, either on the abdominal scar or the breast scar. They can go away on their own or be removed by a doctor.
- Partial or total flap loss, a situation in which the tissue moved to the breast does not get enough blood flow and part or all of it dies. Areas of tissue that fail to thrive need to be surgically removed. The risk of partial flap loss is about 1%; the risk of total flap loss is about 2%. If flap loss happens, it’s still possible to have revision reconstruction to correct it. You may need to wait several months to heal before having revision surgery.
- Fat necrosis, or death of tissue that forms lumps of fat in the breast. Necrosis may occur right after surgery if the blood vessels develop clots in them. All tissue-based reconstructions have a small risk for necrosis. Larger flaps, previous abdominal surgery, and radiation therapy can increase the risk of fat necrosis. Dead tissue needs to be removed by a surgeon.
Delayed vs. immediate DIEP flap reconstruction complications
When you’re making decisions about breast reconstruction, you have the choice between immediate reconstruction or delayed reconstruction.
- In immediate reconstruction, mastectomy is performed at the same time as breast reconstruction.
- In delayed reconstruction, surgery to reconstruct the breast is performed months or even years after mastectomy.
Recent research shows that immediate and delayed DIEP flap surgery are equally safe and have nearly equal rates of surgical complications. The study found that the only complications that differed between immediate and delayed DIEP surgery were with wound healing, such as a wound breaking open, skin necrosis, the wound taking more than 30 days to fully heal, or wounds that required some revision surgery. Overall, the researchers found that these wound issues were more common in people who had delayed DIEP flap surgery.
DIEP flap reconstruction and radiation therapy complications
Some breast cancer treatment plans require radiation therapy after surgery, and whether you need radiation can play a role in your choice of immediate or delayed DIEP flap surgery. One study found that radiation after DIEP flap surgery resulted in more occurrences of flap tissue shrinkage and irregular scarring, while another found that radiation after DIEP flap surgery led to higher rates of fat necrosis and fibrosis (fibrous tissue forming at the surgery site). All of these can impact the way reconstructed breasts look.
If radiation therapy is part of your treatment plan, talk with your breast reconstruction surgeon and your radiation oncologist about timing that works best for both treating the cancer and having a good reconstruction outcome.
Unilateral vs. bilateral DIEP flap reconstruction complications
Another decision you may need to make is whether to have one or both breasts reconstructed. You’re likely to make this decision when you’re thinking through whether to have both breasts removed (double mastectomy). Reasons people choose double mastectomy include:
- Having breast cancer in both breasts
- Having a high risk of breast cancer returning
- Wanting to lower the risk of breast cancer returning
- Testing positive for a high-risk inherited breast cancer mutation such as BRCA1 or BRCA2
Depending on how much abdominal fat you have, DIEP flap reconstruction can recreate one or both breasts. According to a 2017 study in the Annals of Surgical Oncology, the risks increased when DIEP flap surgery reconstructed two breasts instead of one. Researchers don’t know for sure why risk might increase, but they suggest that removing more tissue from the abdomen, and surgeons becoming tired during longer surgeries, may play roles.
According to breast reconstruction surgeon Jonathan Bank, MD, “More surgery means more risk, but in general the risks are manageable and bilateral DIEP flaps remain more common than unilateral ones.”
Paying for DIEP flap surgery
Federal law requires insurance companies to cover breast reconstruction, including DIEP flap surgery. Still, out-of-pocket expenses can vary significantly based on individual policies.
If you are concerned about paying for DIEP flap surgery, talk with your healthcare team. Many cancer centers have financial counselors who can help you plan and find resources. You can also visit our Financial matters section for information on managing costs, finding assistance, and managing your insurance.
Stay connected
Sign up to receive advocacy updates, emotional support, medical insight, personal stories, and more, delivered to your inbox weekly.
Reviewed and updated: December 6, 2024
Reviewed by: Jonathan Bank, MD, FACS , Elisabeth Potter, MD , Sameer A. Patel, MD, FACS
Tagged:
- 3-dimensional radiation therapy
- 4-hydroxytamoxifen
- ablation
- abnormal
- Abraxane
- absolute risk
- AC regimen
- AC-T regimen
- AC-T-T regimen
- AC-Taxol regimen
- AC-TH regimen
- accelerated partial-breast irradiation
- action study
- acupoint
- acupressure
- acupuncture
- acupuncture needle
- acupuncture point
- acupuncture point injection
- acupuncturist
- acustimulation
- acute
- acute pain
- adenocarcinoma
- adenopathy
- adenosis
- adjunct agent
- adjunct therapy
- adjunctive therapy
- adjuvant therapy
- advance directive
- advanced practice nurse
- adverse effect
- aerobic exercise
- agent study
- aggravating factor
- aggressive
- AJCC staging system
- Alkeran
- alkylating agent
- Allegra
- allopathic medicine
- alopecia
- amifostine
- aminoglutethimide
- amitriptyline
- anabolic steroid
- analgesic
- anaplastic
- anastrozole
- ancillary test
- anemia
- anesthesia
- anesthesiologist
- angiogenesis
- angiogenesis inhibitor
- antagonist
- anthracycline
- anti-anxiety medicine
- anti-idiotype vaccine
- anti-inflammatory
- antibody-dependent cellular cytotoxicity
- antibody therapy
- anticachexia
- anticancer antibiotic
- anticancer therapy
- anticonvulsant
- antidepressant
- antiemetic
- antiestrogen
- antifolate
- antigen-presenting cell vaccine
- antihormone therapy
- antimetabolite
- antimitotic agent
- antineoplastic
- antitumor
- anxiety
- anxiolytic
- Anzemet
- APN
- apocrine gland
- apoptosis
- aprepitant
- areola
- Aromasin
- aromatase inhibitor
- aromatherapy
- arthralgia
- ascites
- aspirate
- aspiration
- assay
- asthenia
- asymptomatic
- atypia
- atypical ductal hyperplasia
- atypical hyperplasia
- atypical lobular hyperplasia
- avoidance
- axillary lymph node
- axillary lymph node dissection
- BAK gel
- balloon catheter radiation
- baseline
- behavior modification
- best practice
- BI-RADS
- Biafine cream
- bias
- bilateral
- bilateral breast cancer
- bilateral prophylactic mastectomy
- bilateral salpingo-oophorectomy
- biofeedback
- biologic
- biopsy
- biopsy specimen
- biotherapy
- bisphosphonate
- bisphosphonate-associated osteonecrosis
- blinded study
- blood-brain barrier
- blood-brain barrier disruption
- blood cell count
- blood chemistry study
- board certified oncology pharmacy specialist
- body image
- body mass index
- bolus dose
- bone density
- bone metastasis
- bone mineral density scan
- bone scan
- bone-seeking radioisotope
- brachytherapy
- brain metastasis
- BRCA1
- BRCA2
- BRCAPro
- breast carcinoma in situ
- breast-conserving surgery
- breast density
- breast duct
- breast duct endoscopy
- breast lobe
- breast lobule
- breast reconstruction
- breast self-exam
- Brief Pain Inventory
- cachexia
- CAF regimen
- calcification
- cancer vaccine
- candidiasis
- capecitabine
- carboplatin
- carcinogen
- carcinoma
- carcinoma in situ
- carcinomatous meningitis
- carcinosis
- carcinostatic
- cardiotoxicity
- caregiver
- carmustine
- case-control study
- case report
- case series
- CAT scan
- CBC
- cell
- cell-cycle regulation
- cell proliferation
- central nervous system
- central nervous system metastasis
- central nervous system prophylaxis
- central venous access catheter
- cetuximab
- cevimeline
- chaplain
- charged-particle radiation therapy
- chemoembolization
- chemoimmunotherapy
- chemoprevention
- chemoprevention study
- chemoprotective
- chemoradiation
- chemosensitivity
- chemosensitivity assay
- chemosensitizer
- chemotherapeutic agent
- chemotherapy
- chest wall
- chest X-ray
- Chinese meridian theory
- chronic
- chronic pain
- cisplatin
- Claus model
- clergy
- clinical
- clinical breast exam
- clinical practice guidelines
- clinical researcher
- clinical resistance
- clinical series
- clinical stage
- clinical staging
- clinical study
- clinical trial
- clinician
- clodronate
- CMF regimen
- cognition
- cognitive behavior therapy
- cognitive therapy
- cohort
- cohort study
- coinsurance
- combination chemotherapy
- comedo carcinoma
- comfort care
- Coming Out
- Community Advisory Board
- comorbidity
- compassionate use trial
- complementary and alternative medicine
- complementary medicine
- complete metastasectomy
- complete remission
- complete response
- complex decongestive therapy
- compliance
- complication
- compression garment
- computed tomography scan
- concomitant
- concurrent therapy
- condition
- consolidation therapy
- constitutional acupuncture
- continuum of care
- contract research organization
- contraindication
- contralateral
- contrast material
- control group
- controlled clinical trial
- controlled study
- conventional medicine
- conventional therapy
- copayments
- cope
- coping skills
- core biopsy
- core needle biopsy
- corticosteroid
- counseling
- COX inhibitor
- cryoablation
- cryopreservation
- cryosurgery
- CT scan
- cultural competency
- cumulative dose
- cumulative exposure
- cure
- cutaneous
- cutaneous breast cancer
- cyclophosphamide
- cyclosporine
- CYP2D6 inhibitor
- cystosarcoma phyllodes
- cytopenia
- cytotoxic
- cytotoxic chemotherapy
- Cytoxan
- Data and Safety Monitoring Board
- DCIS
- de novo
- debulking
- deductible
- definitive surgery
- definitive treatment
- dehydration
- denosumab
- depression
- diagnosis
- diagnostic mammogram
- diagnostic procedure
- diagnostic technique
- diagnostic trial
- diameter
- diarrhea
- diaziquone
- DIEP flap
- dietary counseling
- dietary supplement
- dietitian
- differentiation
- diffuse
- digital mammography
- diphenhydramine
- discharge
- disease progression
- disease-specific survival rate
- distant cancer
- distant metastasis
- Distant recurrence
- distress
- DNR order
- docetaxel
- dolasetron
- dose
- dose-dense chemotherapy
- dose-dependent
- dose-limiting
- dose-rate
- double-blinded
- doxorubicin
- drain
- dronabinol
- droperidol
- drug interaction
- drug resistance
- drug therapy
- drug tolerance
- duct
- ductal carcinoma
- ductal carcinoma in situ
- ductal lavage
- duloxetine
- durable power of attorney
- dysfunction
- dysgeusia
- dyspepsia
- dyspnea
- early menopause
- early-stage breast cancer
- edema
- EEG biofeedback
- efficacy
- Eklund displacement views
- electroacupuncture
- electron beam
- eligibility criteria
- Ellence
- emesis
- emetic
- endocrine
- endocrine therapy
- endpoint
- energy healing
- enteral nutrition
- epidemiology
- epirubicin
- ER+
- ER-
- ER
- ER-PR-HER2/neu-
- eribulin mesylate
- erythema
- estradiol
- estrogen
- estrogen blocker
- estrogen receptor
- estrogen receptor-negative
- estrogen receptor-positive
- estrogen receptor test
- estrogen replacement therapy
- etanidazole
- etidronate
- everolimus
- Evista
- excision
- excisional biopsy
- exemestane
- expanded access trial
- experimental
- extranodal
- false-negative test result
- false-positive test result
- familial cancer
- family medical history
- Faslodex
- fast-neutron beam radiation
- fatigue
- FDA
- febrile neutropenia
- FEC regimen
- Femara
- fertility
- fexofenadine
- fibroadenoma
- fibrocystic breast changes
- fiducial marker
- film mammography
- fine-needle aspiration biopsy
- first-degree relative
- first-line therapy
- five-year survival rate
- fluorouracil
- fluoxetine
- FNA biopsy
- focal
- Food and Drug Administration
- Fosamax
- fractionation
- fulvestrant
- functional magnetic resonance imaging
- gadolinium
- Gail model
- gallium scan
- gamma irradiation
- Gamma Knife therapy
- gamma ray
- Gelclair
- gemcitabine
- gene
- gene expression profile
- gene therapy
- general anesthesia
- generalized anxiety disorder
- generic
- genetic
- genetic counseling
- genetic marker
- genetic marker of susceptibility
- genetic predisposition
- genetic profile
- genetic susceptibility
- genetic testing
- genetic testing
- genetics
- genome
- genome-wide association study
- genomic profile
- genomic test
- genomics
- gland
- Good Clinical Practice
- goserelin
- grade
- grading
- granisetron
- gross description
- Halaven
- hazard ratio
- healing touch
- Health Insurance Portability and Accountability Act
- healthcare provider
- healthcare proxy
- healthy control
- helical computed tomography
- HER2/neu
- Herceptin
- hereditary
- hereditary mutation
- heteronormative
- high-dose chemotherapy
- high-dose radiation
- high-energy proton therapy
- high grade
- high-risk cancer
- HIPPA
- histologic examination
- histology
- historic cohort study
- historical control subject
- homeopathic medicine
- hormonal therapy
- hormone
- hormone receptor
- hormone receptor test
- hormone replacement therapy
- hormone responsive
- hormone therapy
- hospice
- hot flash
- human epidermal growth factor receptor 2
- human participant protection regulations
- hydroxydaunorubicin
- hyperalimentation
- hypercalcemia
- hyperfractionated radiation therapy
- hyperfractionation
- hyperplasia
- hypersensitivity
- hypofractionated radiation therapy
- hypofractionation
- hypoxia
- ibandronate
- ibuprofen
- idiopathic
- image-guided radiation therapy
- imaging
- imaging procedure
- immune adjuvant
- immune function
- immune response
- immune system
- immune system tolerance
- immunization
- immunoassay
- immunocompromised
- immunodeficiency
- immunohistochemistry
- immunology
- immunomodulation
- immunosuppression
- immunotherapy
- implant
- implant displacement views
- implant radiation therapy
- implantable pump
- in network
- in situ
- incidence
- incision
- incisional biopsy
- indication
- indolent
- induction therapy
- infection
- infertile
- infertility
- infiltrating breast cancer
- infiltrating ductal carcinoma
- inflammation
- inflammatory breast cancer
- informed consent
- infusion
- ingestion
- inherited
- iniparib
- injection
- inoperable
- insomnia
- Institutional Review Board
- intensification therapy
- intensity-modulated radiation therapy
- interfering thought
- internal mammary lymph nodes
- internal radiation therapy
- International Unit
- internist
- interstitial radiation therapy
- intervention
- intervention group
- intra-arterial
- intracarotid infusion
- intradermal
- intraductal breast papilloma
- intraductal carcinoma
- intrahepatic
- intrahepatic infusion
- intramuscular
- intramuscular injection
- intraoperative radiation therapy
- intraoperative ultrasound
- intratumoral
- intravasation
- intravenous
- intravenous infusion
- intravenous injection
- intrusive thought
- intrusive thoughts
- invasive breast cancer
- invasive cancer
- invasive procedure
- investigational
- investigator
- ionizing radiation
- ipsilateral
- IRB
- irradiated
- irradiation
- irreversible toxicity
- ixabepilone
- joint pain
- Karnofsky Performance Status
- laboratory test
- lapatinib
- laser
- laser surgery
- laser therapy
- lassitude
- late effects
- late-stage cancer
- latent
- laxative
- LEEP
- legal aid organization
- lesion
- lethargy
- letrozole
- leukopenia
- levels of evidence
- Lexapro
- libido
- lidocaine
- ligation
- linac
- linear accelerator
- lipoma
- lisofylline
- liver metastasis
- liver scan
- living will
- lobaplatin
- lobe
- lobectomy
- lobular carcinoma
- lobular carcinoma in situ
- lobule
- local anesthesia
- local cancer
- local therapy
- localization
- localized
- locally advanced cancer
- locally recurrent cancer
- lomustine
- loop electrosurgical excision procedure
- loop excision
- lorazepam
- low grade
- lubricant
- lumbar puncture
- lumpectomy
- lung metastasis
- luteinizing hormone-releasing hormone agonist
- lymph
- lymph gland
- lymph node
- lymph node dissection
- lymph node drainage
- lymph node mapping
- lymph vessel
- lymphadenectomy
- lymphadenopathy
- lymphangiogram
- lymphangiography
- lymphatic basin
- lymphatic fluid
- lymphatic mapping
- lymphatic system
- lymphatic vessel
- lymphedema
- lymphography
- lymphoscintigraphy
- Lyrica
- lytic lesion
- macrocalcification
- magnetic resonance imaging
- magnetic resonance perfusion imaging
- magnetic resonance spectroscopic imaging
- mainstream medicine
- maintenance therapy
- male breast cancer
- malignancy
- malignant
- malignant pleural effusion
- malnutrition
- mammary
- mammary dysplasia
- mammary gland
- mammogram
- mammography
- MammoSite
- Mammotome
- mantle field
- MAO inhibitor
- margin
- marker
- mass
- massage therapy
- mastectomy
- mastitis
- maternal
- maximum tolerated dose
- mean survival time
- measurable disease
- medial supraclavicular lymph node
- median
- median survival time
- Medicaid
- medical castration
- medical device
- medical nutrition therapy
- medical oncologist
- Medicare
- medicine
- medullary breast carcinoma
- mega-voltage linear accelerator
- megestrol
- melphalan
- meningeal metastasis
- menopause
- menorrhagia
- menstrual cycle
- menstrual period
- menstruation
- mental health
- mental health counselor
- meridian
- mesna
- meta-analysis
- metallic
- metastasectomy
- metastasis
- metastasize
- metastatic
- methotrexate
- metoclopramide
- metronomic therapy
- microcalcification
- micrometastasis
- microscopic
- milk duct
- mind/body exercise
- mindfulness relaxation
- Miraluma test
- mitigate
- modified radical mastectomy
- molecular marker
- molecular medicine
- molecular risk assessment
- molecularly targeted therapy
- monoamine oxidase inhibitor
- monoclonal antibody
- morbidity
- mortality
- MRI
- MRSI
- MTD
- mTOR
- mucositis
- multicenter study
- multicentric breast cancer
- multidisciplinary
- multidisciplinary opinion
- multidrug resistance
- multidrug resistance inhibition
- multifocal breast cancer
- music therapy
- mutation
- mutation carrier
- myalgia
- myelosuppression
- nanoparticle paclitaxel
- narcotic
- National Cancer Institute
- National Center for Complementary and Alternative Medicine
- National Institutes of Health
- natural history study
- naturopathy
- nausea
- NCCAM
- NCI
- NCI clinical trials cooperative group
- needle biopsy
- needle localization
- needle-localized biopsy
- negative axillary lymph node
- negative test result
- neoadjuvant therapy
- neoplasm
- nerve
- nerve block
- neurocognitive
- neurologic
- neuropathy
- neurotoxicity
- neurotoxin
- neutropenia
- NIH
- nipple
- nipple discharge
- nitrosourea
- NMRI
- node-negative
- node-positive
- nodule
- nonblinded
- nonconsecutive case series
- noninvasive
- nonmalignant
- nonmetastatic
- nonprescription
- nonrandomized clinical trial
- nonsteroidal anti-inflammatory drug
- nonsteroidal aromatase inhibitor
- nontoxic
- normal range
- normative
- NP
- NPO
- NSAID
- nuclear grade
- nuclear magnetic resonance imaging
- nuclear medicine scan
- nurse
- nurse practitioner
- nutrition
- nutrition therapy
- nutritional counseling
- nutritional status
- nutritional supplement
- nutritionist
- obese
- objective improvement
- objective response
- observation
- observational study
- obstruction
- off-label
- olaparib
- oncologist
- oncology
- oncology nurse
- oncology pharmacy specialist
- oncolysis
- ondansetron
- onset of action
- oophorectomy
- open biopsy
- open label study
- open resection
- operable
- opiate
- opioid
- opportunistic infection
- oral
- organ
- orthodox medicine
- osteolytic
- osteonecrosis of the jaw
- osteopenia
- osteoporosis
- OTC
- out of network
- outcome
- outpatient
- ovarian
- ovarian ablation
- ovarian cancer
- ovarian suppression
- ovary
- over-the-counter
- overall survival rate
- overdose
- overexpress
- overweight
- ovulation
- PA
- paclitaxel
- paclitaxel albumin-stabilized nanoparticle formulation
- paclitaxel-loaded polymeric micelle
- Paget disease of the nipple
- pain threshold
- palliation
- palliative care
- palliative therapy
- palmar-plantar erythrodysesthesia
- palonosetron hydrochloride
- palpable disease
- palpation
- palpitation
- pamidronate
- panic
- papillary tumor
- Paraplatin
- parenteral nutrition
- paroxetine hydrochloride
- PARP
- PARP inhibitor
- partial-breast irradiation
- partial mastectomy
- partial oophorectomy
- partial remission or partial response
- pastoral counselor
- paternal
- pathologic fracture
- pathological stage
- pathological staging
- pathologist
- pathology report
- patient advocate
- Paxil
- peau d'orange
- pedigree
- peer-review process
- peer-reviewed scientific journal
- perfusion magnetic resonance imaging
- perimenopausal
- periodic neutropenia
- perioperative
- peripheral neuropathy
- peripheral venous catheter
- personal health record
- personal medical history
- personalized medicine
- Pertuzumab
- PET scan
- pharmacist
- phase I/II trial
- phase I trial
- phase II/III trial
- phase II trial
- phase III trial
- phase IV trial
- phlebotomy
- photon beam radiation therapy
- phyllodes tumor
- physical examination
- physical therapist
- physical therapy
- physician
- physician assistant
- physiologic
- PI3 kinase inhibitor
- pilocarpine
- pilot study
- placebo
- placebo-controlled
- plastic surgeon
- plastic surgery
- population study
- positive axillary lymph node
- positive test result
- positron emission tomography scan
- post-traumatic stress disorder
- postmenopausal
- postoperative
- postremission therapy
- potentiation
- power of attorney
- PR
- PR+
- PR-
- practitioner
- preauthorization
- precancerous
- preclinical study
- predictive factor
- pregabalin
- premalignant
- premature menopause
- premenopausal
- premium
- prescription
- prevention
- preventive
- preventive mastectomy
- primary care
- primary care doctor
- primary endpoint
- primary therapy
- primary treatment
- primary tumor
- Principal investigator
- prochlorperazine
- progesterone
- progesterone receptor
- progesterone receptor-negative
- progesterone receptor-positive
- progesterone receptor test
- progestin
- prognosis
- prognostic factor
- progression
- progression-free survival
- progressive disease
- Prolia
- proliferative index
- promegapoietin
- prophylactic
- prophylactic mastectomy
- prophylactic oophorectomy
- prophylactic surgery
- prophylaxis
- prospective
- prospective cohort study
- prosthesis
- protective factor
- protein
- protein-bound paclitaxel
- protein expression
- protein expression profile
- protocol
- proton
- proton magnetic resonance spectroscopic imaging
- pruritus
- psychiatrist
- psychological
- psychologist
- psychosocial
- psychotherapy
- PTSD
- pump
- punch biopsy
- qi
- qigong
- quadrantectomy
- quality assurance
- quality of life
- radiation
- radiation brachytherapy
- radiation dermatitis
- radiation fibrosis
- radiation necrosis
- radiation nurse
- radiation oncologist
- radiation physicist
- radiation surgery
- radiation therapist
- radiation therapy
- radical lymph node dissection
- radical mastectomy
- radioactive
- radioactive drug
- radioactive seed
- radioisotope
- radiologic exam
- radiologist
- radiology
- radionuclide
- radionuclide scanning
- radiopharmaceutical
- radiosensitization
- radiosensitizer
- radiosurgery
- radiotherapy
- raloxifene
- raloxifene hydrochloride
- randomization
- randomized clinical trial
- receptor
- RECIST
- reconstructive surgeon
- reconstructive surgery
- recreational therapy
- recurrence
- recurrent cancer
- referral
- reflexology
- refractory
- refractory cancer
- regimen
- regional
- regional anesthesia
- regional cancer
- regional chemotherapy
- regional lymph node
- regional lymph node dissection
- registered dietician
- regression
- rehabilitation
- rehabilitation specialist
- relapse
- relative survival rate
- relaxation technique
- remission
- remission induction therapy
- remote brachytherapy
- research nurse
- research study
- resectable
- resected
- resection
- residual disease
- resistant cancer
- resorption
- respite care
- response rate
- retrospective cohort study
- retrospective study
- risk factor
- Rubex
- salpingo-oophorectomy
- salvage therapy
- samarium 153
- sargramostim
- scalpel
- scan
- scanner
- scintigraphy
- scintimammography
- sclerosing adenosis
- screening
- screening mammogram
- second-line therapy
- second-look surgery
- second primary cancer
- secondary cancer
- secrete
- sedative
- segmental mastectomy
- selection bias
- selective estrogen receptor modulator
- selective serotonin reuptake inhibitor
- sentinel lymph node
- sentinel lymph node biopsy
- sentinel lymph node mapping
- sepsis
- sequential AC/Taxol-Trastuzumab regimen
- sequential treatment
- SERM
- sertraline
- Serzone
- sestamibi breast imaging
- sexuality
- sibling
- side effect
- silicone
- simple mastectomy
- simulation
- Single-agent therapy
- sleep disorder
- social service
- social support
- social worker
- sodium thiosulfate
- soft tissue
- solid tumor
- somatic
- somatic mutation
- sorafenib
- specialist
- specificity
- spiculated mass
- spinal anesthesia
- spinal block
- spiral CT scan
- spirituality
- sporadic cancer
- SSRI
- stable disease
- stage
- stage 0 breast carcinoma in situ
- stage 0 disease
- stage I breast cancer
- stage IA breast cancer
- stage IB breast cancer
- stage II breast cancer
- stage II breast cancer
- stage IIA breast cancer
- stage IIB breast cancer
- stage III breast cancer
- stage III lymphedema
- stage IIIA breast cancer
- stage IIIB breast cancer
- stage IIIC breast cancer
- stage IV breast cancer
- staging
- stamina
- standard of care
- standard therapy
- statistically significant
- stent
- stereotactic biopsy
- stereotactic radiosurgery
- sterile
- sternum
- steroid
- stress
- strontium
- study agent
- subcutaneous
- subcutaneous port
- subjective improvement
- subset analysis
- supplemental nutrition
- supplementation
- support group
- supportive care
- supraclavicular lymph node
- surgeon
- surgery
- surgical biopsy
- surgical menopause
- surgical oncologist
- survival rate
- symptom
- symptom management
- symptomatic
- synergistic
- synthetic
- syringe
- systemic
- systemic chemotherapy
- systemic disease
- systemic therapy
- TAC regimen
- tai chi
- tailored intervention
- talk therapy
- tamoxifen
- targeted therapy
- taxane
- Taxol
- Taxotere
- Tc 99m sulfur colloid
- technician
- terminal disease
- therapeutic
- therapeutic touch
- therapy
- thermography
- thiethylperazine
- thiotepa
- third-line therapy
- thrush
- time to progression
- tinnitus
- tissue
- tissue flap reconstruction
- TNM staging system
- tomography
- tomotherapy
- topical
- topical chemotherapy
- topoisomerase inhibitor
- total estrogen blockade
- total mastectomy
- total nodal irradiation
- total parenteral nutrition
- toxic
- toxicity
- tracer
- traditional acupuncture
- tranquilizer
- transdermal
- transfusion
- transitional care
- translational research
- trastuzumab
- trauma
- treatment field
- trigger
- trigger point acupuncture
- triple-negative breast cancer
- tumescent mastectomy
- tumor
- tumor antigen vaccine
- tumor board review
- tumor burden
- tumor debulking
- tumor load
- tumor marker
- tumor volume
- Tykerb
- ulcer
- ulceration
- ultrasound-guided biopsy
- ultrasound/ultrasonography
- ultraviolet radiation therapy
- uncontrolled study
- undifferentiated
- unilateral
- unilateral salpingo-oophorectomy
- unresectable
- unresected
- upstaging
- urticaria
- VACB
- vaccine therapy
- vacuum-assisted biopsy or vacuum-assisted core biopsy
- Valium
- vancomycin
- vandetanib
- vascular endothelial growth factor-antisense oligonucleotide
- vascular endothelial growth factor receptor tyrosine kinase inhibitor
- vein
- Velban
- venipuncture
- venous sampling
- Versed
- vertebroplasty
- vinorelbine
- vital
- vomit
- watchful waiting
- wedge resection
- Wellcovorin
- Western medicine
- WGA study
- white blood cell
- whole cell vaccine
- whole genome association study
- wide local excision
- wire localization
- wound
- X-ray therapy
- Xanax
- Xeloda
- xerostomia
- Xgeva
- yoga
- ziconotide
- Zinecard
- Zofran
- zoledronic acid
- Zoloft
- Zometa
Living Beyond Breast Cancer is a national nonprofit organization that seeks to create a world that understands there is more than one way to have breast cancer. To fulfill its mission of providing trusted information and a community of support to those impacted by the disease, Living Beyond Breast Cancer offers on-demand emotional, practical, and evidence-based content. For over 30 years, the organization has remained committed to creating a culture of acceptance — where sharing the diversity of the lived experience of breast cancer fosters self-advocacy and hope. For more information, learn more about our programs and services.