Can a breast cancer diagnosis be wrong?
- Medical Review: Brian S. Englander, MD
It is unusual, but possible, for breast cancer tests and even a breast cancer diagnosis to be inaccurate. Before breast cancer is diagnosed, a person typically has screening mammography and other diagnostic tests. These may show abnormal results or suspicious tissue that do not always turn out to be breast cancer. It is also possible for a screening test alone, without further study, to miss suspicious tissue or other signs you may have breast cancer.
It is less common for a breast cancer diagnosis to be incorrect. No test is perfect. It is possible that an expert has looked at tissue taken from a biopsy and said you had cancer when you do not or has said you do not have cancer when you do. In the United States, there are currently no standards in place to track how often that happens. Different sources say that a very small percentage of U.S. breast cancer diagnoses could be incorrect. Fortunately, there are things you can do to be more certain in your diagnosis and test results.
How do diagnosis mistakes happen?
Here are some examples:
- If the doctor is not a breast cancer specialist, it’s possible that a symptom could be overlooked that a specialist is more likely to recognize.
- Clinical errors can sometimes happen when doctors are looking at symptoms and performing a physical exam. One example is inflammatory breast cancer (IBC), which looks different from most breast cancers in that it may not cause a lump. Some doctors may not recognize IBC during a clinical exam and may mistake it for infection or non-cancerous inflammation.
- Tests can have false-negative and false-positive results:
- A false-negative result says that there is no cancer present when there actually is cancer present.
- A false-positive result, on the other hand, appears to be abnormal even though no cancer is present.
- While no breast cancer test is perfect, a diagnosis is closer to certain once the suspicious tissue is removed from the breast and examined by a pathologist, a doctor who diagnoses diseases by studying cells and tissue under a microscope. Even then, pathology errors can happen. Examples include errors identifying the type of cancer or whether the cancer has certain features. Still, in many cases, pathologists agree with each other.
If you have concerns about whether your diagnosis is accurate, seeking a second opinion with another doctor can help you better understand and feel more confident about your diagnosis. Learn more about deciding whether you should get a second opinion.
While an abnormal test result can cause feelings of anxiety, if you have an abnormal result, it is important to follow up with your doctor for next steps. Don’t wait. If it turns out to be breast cancer, you and your healthcare team may be finding it at an earlier stage, when it’s easier to treat. You might receive confirmation that it is not breast cancer.
Some breast cancers found by screening mammogram turn out not to be life-threatening. But doctors can’t always predict whether a breast cancer is likely to grow or spread from the breast. Because of this uncertainty, standard practice today is to treat all diagnosed breast cancers.
Technology to diagnose breast cancer is continuing to improve and helping to reduce possible overdiagnosis. Research is also helping doctors define which cancers are life-threatening and which are not. Advances in medicine are allowing doctors to focus more specifically on a person’s unique medical history, genetics, and tumor characteristics to use the most effective screening and treatment plan. This is called precision medicine. Learn more about precision medicine.
Below, you can find more information about the benefits and limitations of common breast cancer diagnostic tests, as well as support resources to help you and your loved ones navigate a breast cancer diagnosis.
Accuracy of breast cancer screening tests
Each breast cancer test has strengths and limitations. This includes the test’s sensitivity and specificity:
- Sensitivity measures how effectively a test identifies that a person actually has breast cancer.
- Specificity measures how effectively a test identifies that a person does not have breast cancer.
The closer the test sensitivity and specificity approach 100%, the more likely it is that a person does or does not have breast cancer. At the same time, it is important to understand that a highly sensitive test could bring a false-positive result because it may pick up things that seem even slightly abnormal. Likewise, a test that is highly specific can overlook tissue that may be cancer and give a false-negative result. The most effective screening tests have both high sensitivity and high specificity.
Below, we’ll walk you through three common screening and diagnostic imaging tests: mammograms, ultrasounds, and biopsies.
Mammograms
Mammograms are x-ray pictures of the breast. They are the most effective breast cancer screening method available today, looking across broad groups of people who get screened for breast cancer.
Screening mammograms look for signs of cancer in people with no symptoms. Diagnostic mammograms are used if there are breast symptoms or changes seen on screening mammograms. Diagnostic mammograms can also be used to monitor people who have completed breast cancer treatment. Both screening and diagnostic mammograms consist of x-ray images of the breast, but they may differ in the types of pictures taken because they have different goals.
Even though mammograms are the best screening tool we have, they are not perfect, and additional tests are often needed to confirm a diagnosis. Mammograms can sometimes have false-positive and false-negative results:
- False-positive mammogram results tend to happen in younger women, women with dense breasts, women who have had breast biopsies, and women who have a family history of breast cancer.
- The likelihood of a false-positive mammogram is highest when you’re having your first mammogram. The chance of having a false-positive finding drops by about 50% once you have prior mammograms available for comparison.
- In women with dense breast tissue, false-negative test results are more likely. Dense breasts are more common in women under age 40, those with a low body mass index, and older women taking combination hormonal replacement therapy.
- If previous tests have shown that you have dense breast tissue, your doctor may recommend additional testing for you.
Data gathered by the Breast Cancer Surveillance Consortium report screening mammogram sensitivity rates to be as high as 86.9% and specificity rates to be as high as 88.9%. However, the sensitivity and specificity of mammography depend on many factors, including how dense the breasts are and how complex the breasts are, meaning how certain tissues are arranged. Some studies show that up to 20% of breast cancers cannot be detected on screening mammograms.
Certain types of breast cancer, such as invasive lobular cancer, may not easily be found with mammography. Diagnosing hard-to-detect breast cancers may require additional testing, such as clinical exam by a breast cancer specialist, ultrasound, MRI, or a nuclear medicine test.
If you’re concerned about radiation from mammograms, the amount of radiation is small and the exposure is low. The benefits of mammogram for early detection far outweigh any potential harm from radiation exposure.
If you receive an abnormal mammogram result, your doctor will talk with you about next steps. This may mean having additional tests to get more information, such as further imaging tests or a needle or surgical biopsy to examine a sample of breast tissue.
Learn more about mammograms.
Ultrasounds
Breast ultrasound takes pictures of the breast using sound waves. This test can pick up masses, infections, fluid-filled cysts, and other changes that are often not cancer. These changes aren’t always easy to see on mammograms because of the overlying breast tissue.
The most common reasons your doctor may recommend an ultrasound include:
- If a lump can be felt in the breast, but a mammogram doesn’t find it
- If more images are needed for a suspicious finding on a mammogram
- If there are changes in dense breast tissue
- If the doctor needs to check the difference between solid masses, which may be cancer, and fluid-filled cysts, which are far less likely to be cancer
Ultrasound is an easy and painless test to have, and it uses no radiation. However, ultrasound does not pick up tiny calcifications, the calcium deposits that, when found in certain patterns, can be signs of breast cancer. Mammograms pick up calcifications more effectively.
False-positive and false-negative results can also happen with ultrasound. In women with dense breasts, more cancers are found when a breast ultrasound is done in addition to mammography, but adding ultrasound to the screening also can result in more false-positives. Because of this, it is not recommended to use ultrasound alone to screen for breast cancer. Instead, it is often used as a follow-up after mammogram or other tests or as supplemental screening for breast cancer.
If you receive a positive result after a breast ultrasound, your doctor may recommend a breast biopsy to examine the cells under a microscope and test them directly.
Visit the ultrasound page to learn more.
Biopsies
A breast biopsy is a procedure that removes a small amount of tissue from the breast so that it can be studied in the lab. Depending on the situation, biopsies can be minimally invasive or more extensive. Some biopsies can be done with a needle in the doctor’s office. Other situations may require a surgeon making a small incision (cut) to remove the tissue in the operating room.
A biopsy is usually recommended if a mammogram or other tests suggest that breast cancer cells may be present. After a biopsy is performed and the tissue is examined, you will be given a pathology report that explains what was found. If cancer is found, the report includes information about the features of the cancer. This includes the cancer location, type, stage, hormone-receptor status, and other traits.
While the results of a biopsy are more accurate than results from a mammogram, ultrasound, or other imaging tests, errors can still happen. Different sources believe a very small percentage of U.S. breast cancer diagnoses could be incorrect.
Visit biopsy and understanding your pathology report pages for more information.
Accepting your diagnosis
If doctors discover that you have been accurately diagnosed with breast cancer, you may be experiencing many different emotions. Anger, fear, sadness, and confusion are all common emotional responses to a new breast cancer diagnosis.
In our emotional health section, you and the people close to you can find information about processing feelings after a diagnosis, talking with loved ones, and creating an emotional support network. You can also visit the links below:
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- refractory
- refractory cancer
- regimen
- regional
- regional anesthesia
- regional cancer
- regional chemotherapy
- regional lymph node
- regional lymph node dissection
- registered dietician
- regression
- rehabilitation
- rehabilitation specialist
- relapse
- relative survival rate
- relaxation technique
- remission
- remission induction therapy
- remote brachytherapy
- research nurse
- research study
- resectable
- resected
- resection
- residual disease
- resistant cancer
- resorption
- respite care
- response rate
- retrospective cohort study
- retrospective study
- risk factor
- Rubex
- salpingo-oophorectomy
- salvage therapy
- samarium 153
- sargramostim
- scalpel
- scan
- scanner
- scintigraphy
- scintimammography
- sclerosing adenosis
- screening
- screening mammogram
- second-line therapy
- second-look surgery
- second primary cancer
- secondary cancer
- secrete
- sedative
- segmental mastectomy
- selection bias
- selective estrogen receptor modulator
- selective serotonin reuptake inhibitor
- sentinel lymph node
- sentinel lymph node biopsy
- sentinel lymph node mapping
- sepsis
- sequential AC/Taxol-Trastuzumab regimen
- sequential treatment
- SERM
- sertraline
- Serzone
- sestamibi breast imaging
- sexuality
- sibling
- side effect
- silicone
- simple mastectomy
- simulation
- Single-agent therapy
- sleep disorder
- social service
- social support
- social worker
- sodium thiosulfate
- soft tissue
- solid tumor
- somatic
- somatic mutation
- sorafenib
- specialist
- specificity
- spiculated mass
- spinal anesthesia
- spinal block
- spiral CT scan
- spirituality
- sporadic cancer
- SSRI
- stable disease
- stage
- stage 0 breast carcinoma in situ
- stage 0 disease
- stage I breast cancer
- stage IA breast cancer
- stage IB breast cancer
- stage II breast cancer
- stage II breast cancer
- stage IIA breast cancer
- stage IIB breast cancer
- stage III breast cancer
- stage III lymphedema
- stage IIIA breast cancer
- stage IIIB breast cancer
- stage IIIC breast cancer
- stage IV breast cancer
- staging
- stamina
- standard of care
- standard therapy
- statistically significant
- stent
- stereotactic biopsy
- stereotactic radiosurgery
- sterile
- sternum
- steroid
- stress
- strontium
- study agent
- subcutaneous
- subcutaneous port
- subjective improvement
- subset analysis
- supplemental nutrition
- supplementation
- support group
- supportive care
- supraclavicular lymph node
- surgeon
- surgery
- surgical biopsy
- surgical menopause
- surgical oncologist
- survival rate
- symptom
- symptom management
- symptomatic
- synergistic
- synthetic
- syringe
- systemic
- systemic chemotherapy
- systemic disease
- systemic therapy
- TAC regimen
- tai chi
- tailored intervention
- talk therapy
- tamoxifen
- targeted therapy
- taxane
- Taxol
- Taxotere
- Tc 99m sulfur colloid
- technician
- terminal disease
- therapeutic
- therapeutic touch
- therapy
- thermography
- thiethylperazine
- thiotepa
- third-line therapy
- thrush
- time to progression
- tinnitus
- tissue
- tissue flap reconstruction
- TNM staging system
- tomography
- tomotherapy
- topical
- topical chemotherapy
- topoisomerase inhibitor
- total estrogen blockade
- total mastectomy
- total nodal irradiation
- total parenteral nutrition
- toxic
- toxicity
- tracer
- traditional acupuncture
- tranquilizer
- transdermal
- transfusion
- transitional care
- translational research
- trastuzumab
- trauma
- treatment field
- trigger
- trigger point acupuncture
- triple-negative breast cancer
- tumescent mastectomy
- tumor
- tumor antigen vaccine
- tumor board review
- tumor burden
- tumor debulking
- tumor load
- tumor marker
- tumor volume
- Tykerb
- ulcer
- ulceration
- ultrasound-guided biopsy
- ultrasound/ultrasonography
- ultraviolet radiation therapy
- uncontrolled study
- undifferentiated
- unilateral
- unilateral salpingo-oophorectomy
- unresectable
- unresected
- upstaging
- urticaria
- VACB
- vaccine therapy
- vacuum-assisted biopsy or vacuum-assisted core biopsy
- Valium
- vancomycin
- vandetanib
- vascular endothelial growth factor-antisense oligonucleotide
- vascular endothelial growth factor receptor tyrosine kinase inhibitor
- vein
- Velban
- venipuncture
- venous sampling
- Versed
- vertebroplasty
- vinorelbine
- vital
- vomit
- watchful waiting
- wedge resection
- Wellcovorin
- Western medicine
- WGA study
- white blood cell
- whole cell vaccine
- whole genome association study
- wide local excision
- wire localization
- wound
- X-ray therapy
- Xanax
- Xeloda
- xerostomia
- Xgeva
- yoga
- ziconotide
- Zinecard
- Zofran
- zoledronic acid
- Zoloft
- Zometa
Living Beyond Breast Cancer is a national nonprofit organization that seeks to create a world that understands there is more than one way to have breast cancer. To fulfill its mission of providing trusted information and a community of support to those impacted by the disease, Living Beyond Breast Cancer offers on-demand emotional, practical, and evidence-based content. For over 30 years, the organization has remained committed to creating a culture of acceptance — where sharing the diversity of the lived experience of breast cancer fosters self-advocacy and hope. For more information, learn more about our programs and services.